Welcome to the McLellan Lab

Our lab focuses on understanding the links between environmental processes and human health. Microbes underpin many of these processes and are key agents in human health and disease. We explore human and animal microbiome community structure to identify new indicators of waterborne disease threats, and investigate what the distribution of these organisms can tell us about urban impacts on freshwater resources. We also examine the urban water microbiome to understand how bacteria survive and adapt in new environments. Our research is important to devise management strategies, inform water policy, and ultimately solve pollution problems and protect human health.

Alternative Indicators

We are taking an entirely new approach for pathogen surveillance by using next generation sequencing technologies to characterize the complex microbiomes of humans and animals and develop new water quality indicators that provide information as to the source of pollution.


Climate, Health and the coastal environment

Our lab is quantifying agricultural runoff and sewage pollution impacts on estuaries and the Great Lakes. We have found that stormwater has a human pollution signal from failing sewers, an unrecognized but serious source of pathogens to waterways. This research examines the links between climate, extreme events, and human health risks in the nearshore.


Beaches

Elevated E. coli levels are the cause of beach closings around the Great Lakes. Our research focuses on understanding the genomic basis and adaptive traits of E. coli that can survive and even grow in the sand, which severely confounds monitoring efforts since many agencies still use this organism as a water quality indicator at beaches.


Urban Water Microbiome

Urban microbial ecology is an emerging field that will impact how we build our cities and maintain clean water. We have found that the urban sewer infrastructure contains a highly abundant resident microbial community. Members of this pipe community are likely excellent models to understand basic questions of how microbes adapt to new environments created by human activity.